The Mettler Toledo M400 Type 2 ISM is a four-wire, single-channel process transmitter designed for pharmaceutical and life science analytical measurement applications.
It connects with digital Intelligent Sensor Management (ISM) sensors to monitor pH/ORP, conductivity, dissolved oxygen, and dissolved carbon dioxide.
The transmitter combines multi-parameter flexibility with sensor recognition and diagnostic capabilities.
When an ISM sensor is connected, stored identification, calibration, and operating information is transferred to the transmitter, helping simplify sensor installation, commissioning, and maintenance planning.
Key Characteristics
- Four-wire, single-channel transmitter configuration
- Compatible with digital ISM sensors
- Supports pH/ORP, conductivity, oxygen, and dissolved CO₂ measurement
- Plug and Measure functionality for automatic sensor recognition
- ISM diagnostic tools, including Dynamic Lifetime Indicator, Adaptive Calibration Timer, and Time to Maintenance
- Four configurable 0/4–20 mA outputs
- HART communication
- Two digital inputs
- Integrated PID process-control functionality
- 100–240 VAC or 20–30 VDC power options
- 4.0-inch black-and-white TFT user interface
- Hazardous area approvals, including ATEX/IECEx Zone 2, FM/cFMus Class I Division 2, and NEPSI Zone 2
- CE and UL compliance
- Enclosure suitable for panel, wall, or pipe-mounted process installations
Ideal Applications
- In-line pH and ORP monitoring
- Conductivity measurement in process liquids and pharmaceutical water systems
- Dissolved oxygen monitoring during fermentation and cell-culture processes
- Dissolved carbon dioxide measurement in pharmaceutical and bioprocess applications
- Analytical loops requiring digital sensor diagnostics
- Applications requiring pre-calibrated sensor replacement
- Processes where predictive calibration and maintenance information can support planned service activities
- Integration with plant control and asset-management systems through analog outputs and HART communication
Parameters
- Conductivity
- Dissolved CO2
- Dissolved Oxygen
- Dissolved Ozone
- ORP
- Optical DO
- pH
Communication
- HART
Product Family Includes
- M400 Type 2 ISM — Four-wire, single-channel transmitter for digital ISM pH/ORP, conductivity, oxygen, and dissolved CO₂ sensors
Industries Served
- Pharmaceutical Manufacturing
- Biopharmaceutical Production
- Biotechnology
- Life Science Manufacturing
- Fermentation and Cell-culture Processing
- Other Industrial Processes
- Pharmaceutical/Life Science Production
Related Products
Mettler Toledo ISM Digital Sensor Accessories
Mettler Toledo M300 Process Transmitters (4-Wire)
Mettler Toledo M400 Process Transmitters (4-Wire)
Mettler Toledo M800 Process Transmitters (4-Wire)
Mettler Toledo M400 Process Transmitters (2-Wire)